This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1pl6

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Human SDH/NADH/inhibitor complex

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pl6"

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1pl6.png|left|200px]]
-<!--
+==Human SDH/NADH/inhibitor complex==
-The line below this paragraph, containing "STRUCTURE_1pl6", creates the "Structure Box" on the page.
+<StructureSection load='1pl6' size='340' side='right'caption='[[1pl6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1pl6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=572:4-[2-(HYDROXYMETHYL)PYRIMIDIN-4-YL]-N,N-DIMETHYLPIPERAZINE-1-SULFONAMIDE'>572</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1pl6|  PDB=1pl6  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl6 OCA], [https://pdbe.org/1pl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl6 ProSAT]</span></td></tr>
+</table>
-===Human SDH/NADH/inhibitor complex===
+== Function ==
+[https://www.uniprot.org/uniprot/DHSO_HUMAN DHSO_HUMAN] Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).<ref>PMID:16278369</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_12962626}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 12962626 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl6_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_12962626}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-PL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL6 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl6 ConSurf].
+<div style="clear:both"></div>
-==Reference==
+== References ==
-X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase., Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL, Structure. 2003 Sep;11(9):1071-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12962626 12962626]
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: L-iditol 2-dehydrogenase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Adams PD]]
-[[Category: Adams, P D.]]
+[[Category: Beebe DA]]
-[[Category: Beebe, D A.]]
+[[Category: Chrunyk B]]
-[[Category: Chrunyk, B.]]
+[[Category: Cunningham D]]
-[[Category: Cunningham, D.]]
+[[Category: Ekstrom JL]]
-[[Category: Ekstrom, J L.]]
+[[Category: Griffor M]]
-[[Category: Griffor, M.]]
+[[Category: Kamath A]]
-[[Category: Kamath, A.]]
+[[Category: Lee SE]]
-[[Category: Lee, S E.]]
+[[Category: Madura R]]
-[[Category: Madura, R.]]
+[[Category: Mcguire D]]
-[[Category: Mcguire, D.]]
+[[Category: Mylari BL]]
-[[Category: Mylari, B L.]]
+[[Category: Oates PJ]]
-[[Category: Oates, P J.]]
+[[Category: Pauly TA]]
-[[Category: Pauly, T A.]]
+[[Category: Rath VL]]
-[[Category: Rath, V L.]]
+[[Category: Subashi T]]
-[[Category: Subashi, T.]]
+[[Category: Wasilko D]]
-[[Category: Wasilko, D.]]
+[[Category: Watts P]]
-[[Category: Watts, P.]]
-[[Category: Cp-166,572]]
-[[Category: Sorbitol dehydrogenase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:51:20 2008''

1pl6

From Proteopedia

Current revision

Human SDH/NADH/inhibitor complex

Structural highlights

Function

Evolutionary Conservation

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox