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1pne

From Proteopedia

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{{Seed}}
 
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[[Image:1pne.png|left|200px]]
 
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==CRYSTALLIZATION AND STRUCTURE DETERMINATION OF BOVINE PROFILIN AT 2.0 ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_1pne", creates the "Structure Box" on the page.
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<StructureSection load='1pne' size='340' side='right'caption='[[1pne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PNE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_1pne| PDB=1pne | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pne OCA], [https://pdbe.org/1pne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pne RCSB], [https://www.ebi.ac.uk/pdbsum/1pne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pne ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PROF1_BOVIN PROF1_BOVIN] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pne_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pne ConSurf].
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<div style="clear:both"></div>
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===CRYSTALLIZATION AND STRUCTURE DETERMINATION OF BOVINE PROFILIN AT 2.0 ANGSTROMS RESOLUTION===
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==See Also==
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8046751}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8046751 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8046751}}
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==About this Structure==
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1PNE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNE OCA].
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==Reference==
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<ref group="xtra">PMID:8046751</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Cedergren-Zeppezauer, E S.]]
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[[Category: Large Structures]]
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[[Category: Dauter, Z.]]
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[[Category: Cedergren-Zeppezauer ES]]
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[[Category: Goonesekere, N C.W.]]
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[[Category: Dauter Z]]
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[[Category: Lindberg, U.]]
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[[Category: Goonesekere NCW]]
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[[Category: Myslik, J C.]]
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[[Category: Lindberg U]]
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[[Category: Rozycki, M D.]]
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[[Category: Myslik JC]]
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[[Category: Schutt, C E.]]
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[[Category: Rozycki MD]]
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[[Category: Actin binding protein]]
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[[Category: Schutt CE]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:38:36 2009''
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Current revision

CRYSTALLIZATION AND STRUCTURE DETERMINATION OF BOVINE PROFILIN AT 2.0 ANGSTROMS RESOLUTION

PDB ID 1pne

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