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1prw

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(New page: 200px<br /><applet load="1prw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1prw, resolution 1.70&Aring;" /> '''Crystal structure of...)
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[[Image:1prw.jpg|left|200px]]<br /><applet load="1prw" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1prw, resolution 1.70&Aring;" />
 
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'''Crystal structure of bovine brain Ca++ calmodulin in a compact form'''<br />
 
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==Overview==
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==Crystal structure of bovine brain Ca++ calmodulin in a compact form==
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Calmodulin has been a subject of intense scrutiny since its discovery, because of its unusual properties in regulating the functions of about 100, diverse target enzymes and structural proteins. The original and to date, only crystal conformation of native eukaryotic Ca(2+)-calmodulin, (Ca(2+)-CaM) is a very extended molecule with two widely separated, globular domains linked by an exposed long helix. Here we report the 1.7 A, X-ray structure of a new native Ca(2+)-CaM that is in a compact, ellipsoidal conformation and shows a sharp bend in the linker helix and a, more contracted N-terminal domain. This conformation may offer advantages, for recognition of kinase-type calmodulin targets or small organic, molecule drugs.
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<StructureSection load='1prw' size='340' side='right'caption='[[1prw]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1prw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PRW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1prw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prw OCA], [https://pdbe.org/1prw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1prw RCSB], [https://www.ebi.ac.uk/pdbsum/1prw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1prw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CALM_BOVIN CALM_BOVIN] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1prw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1prw ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1PRW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA and ACE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PRW OCA].
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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==Reference==
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__TOC__
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A closed compact structure of native Ca(2+)-calmodulin., Fallon JL, Quiocho FA, Structure. 2003 Oct;11(10):1303-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14527397 14527397]
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Fallon, J.L.]]
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[[Category: Fallon JL]]
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[[Category: Quiocho, F.A.]]
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[[Category: Quiocho FA]]
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[[Category: ACE]]
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[[Category: CA]]
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[[Category: calcium-binding protein]]
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[[Category: ef hand]]
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[[Category: kinase activator]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:04:06 2007''
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Current revision

Crystal structure of bovine brain Ca++ calmodulin in a compact form

PDB ID 1prw

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