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1q2b

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[[Image:1q2b.png|left|200px]]
 
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{{STRUCTURE_1q2b| PDB=1q2b | SCENE= }}
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==CELLOBIOHYDROLASE CEL7A WITH DISULPHIDE BRIDGE ADDED ACROSS EXO-LOOP BY MUTATIONS D241C AND D249C==
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<StructureSection load='1q2b' size='340' side='right'caption='[[1q2b]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===CELLOBIOHYDROLASE CEL7A WITH DISULPHIDE BRIDGE ADDED ACROSS EXO-LOOP BY MUTATIONS D241C AND D249C===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q2B FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14568538}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q2b OCA], [https://pdbe.org/1q2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q2b RCSB], [https://www.ebi.ac.uk/pdbsum/1q2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q2b ProSAT]</span></td></tr>
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[[1q2b]] is a 1 chain structure of [[Cellobiohydrolase]] and [[Glucanase]] with sequence from [http://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2B OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUX1_HYPJE GUX1_HYPJE] The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q2/1q2b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q2b ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cellobiohydrolase|Cellobiohydrolase]]
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*[[Cellobiohydrolase 3D structures|Cellobiohydrolase 3D structures]]
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*[[Glucanase|Glucanase]]
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014568538</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Cellulose 1,4-beta-cellobiosidase]]
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[[Category: Trichoderma reesei]]
[[Category: Trichoderma reesei]]
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[[Category: Harris, M.]]
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[[Category: Harris M]]
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[[Category: Jones, T A.]]
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[[Category: Jones TA]]
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[[Category: Stahlberg, J.]]
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[[Category: Stahlberg J]]
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[[Category: Cellulase]]
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[[Category: Cellulose degradation]]
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[[Category: Disulphide mutant]]
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[[Category: Glycoprotein]]
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[[Category: Glycosidase]]
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[[Category: Glycosylated protein]]
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[[Category: Hydrolase]]
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Current revision

CELLOBIOHYDROLASE CEL7A WITH DISULPHIDE BRIDGE ADDED ACROSS EXO-LOOP BY MUTATIONS D241C AND D249C

PDB ID 1q2b

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