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1q43

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{{Seed}}
 
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[[Image:1q43.png|left|200px]]
 
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==HCN2I 443-640 in the presence of cAMP, selenomethionine derivative==
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The line below this paragraph, containing "STRUCTURE_1q43", creates the "Structure Box" on the page.
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<StructureSection load='1q43' size='340' side='right'caption='[[1q43]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q43]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q43 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1q43| PDB=1q43 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q43 OCA], [https://pdbe.org/1q43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q43 RCSB], [https://www.ebi.ac.uk/pdbsum/1q43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q43 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q4/1q43_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q43 ConSurf].
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<div style="clear:both"></div>
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===HCN2I 443-640 in the presence of cAMP, selenomethionine derivative===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12968185 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12968185}}
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==About this Structure==
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1Q43 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q43 OCA].
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==Reference==
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Structural basis for modulation and agonist specificity of HCN pacemaker channels., Zagotta WN, Olivier NB, Black KD, Young EC, Olson R, Gouaux E, Nature. 2003 Sep 11;425(6954):200-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12968185 12968185]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Black KD]]
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[[Category: Black, K D.]]
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[[Category: Gouaux JE]]
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[[Category: Gouaux, J E.]]
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[[Category: Olivier NB]]
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[[Category: Olivier, N B.]]
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[[Category: Olson R]]
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[[Category: Olson, R.]]
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[[Category: Young EC]]
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[[Category: Young, E C.]]
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[[Category: Zagotta WN]]
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[[Category: Zagotta, W N.]]
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[[Category: C-linker]]
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[[Category: Camp]]
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[[Category: Cap]]
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[[Category: Channel]]
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[[Category: Cnbd]]
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[[Category: Cyclic nucleotide]]
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[[Category: Hcn,hcn2]]
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[[Category: Ion channel]]
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[[Category: Ligand]]
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[[Category: Pacemaker]]
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[[Category: Pka]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:55:12 2008''
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Current revision

HCN2I 443-640 in the presence of cAMP, selenomethionine derivative

PDB ID 1q43

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