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1q55

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(New page: 200px<br /><applet load="1q55" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q55" /> '''W-shaped trans interactions of cadherins mod...)
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[[Image:1q55.gif|left|200px]]<br /><applet load="1q55" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1q55" />
 
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'''W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography'''<br />
 
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==Overview==
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==W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography==
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Cell adhesion by adherens junctions and desmosomes relies on interactions, between cadherin molecules. However, the molecular interfaces that define, molecular specificity and that mediate adhesion remain controversial. We, used electron tomography of plastic sections from neonatal mouse skin to, visualize the organization of desmosomes in situ. The resulting, three-dimensional maps reveal individual cadherin molecules forming, discrete groups and interacting through their tips. Fitting of an x-ray, crystal structure for C-cadherin to these maps is consistent with a, flexible intermolecular interface mediated by an exchange of, amino-terminal tryptophans. This flexibility suggests a novel mechanism, for generating both cis and trans interactions and for propagating these, adhesive interactions along the junction.
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<SX load='1q55' size='340' side='right' viewer='molstar' caption='[[1q55]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q55]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q55 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 30&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q55 OCA], [https://pdbe.org/1q55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q55 RCSB], [https://www.ebi.ac.uk/pdbsum/1q55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q55 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q55_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q55 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Q55 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, NDG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Q55 OCA].
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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__TOC__
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==Reference==
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</SX>
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Untangling desmosomal knots with electron tomography., He W, Cowin P, Stokes DL, Science. 2003 Oct 3;302(5642):109-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14526082 14526082]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Cowin P]]
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[[Category: Cowin, P.]]
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[[Category: He W]]
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[[Category: He, W.]]
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[[Category: Stokes DL]]
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[[Category: Stokes, D.L.]]
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[[Category: CA]]
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[[Category: NAG]]
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[[Category: NDG]]
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[[Category: cadherin; trans interaction; desmosome; junction; adhesion]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:34:57 2007''
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Current revision

W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography

1q55, resolution 30.00Å

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