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1qdb

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[[Image:1qdb.jpg|left|200px]]
 
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{{Structure
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==CYTOCHROME C NITRITE REDUCTASE==
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|PDB= 1qdb |SIZE=350|CAPTION= <scene name='initialview01'>1qdb</scene>, resolution 1.90&Aring;
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<StructureSection load='1qdb' size='340' side='right'caption='[[1qdb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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<table><tr><td colspan='2'>[[1qdb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurospirillum_deleyianum Sulfurospirillum deleyianum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QDB FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdb OCA], [https://pdbe.org/1qdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qdb RCSB], [https://www.ebi.ac.uk/pdbsum/1qdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qdb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NRFA_SULDE NRFA_SULDE] Plays a role in nitrite reduction.[HAMAP-Rule:MF_01182]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qdb ConSurf].
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<div style="clear:both"></div>
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'''CYTOCHROME C NITRITE REDUCTASE'''
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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*[[Cytochrome c nitrite reductase|Cytochrome c nitrite reductase]]
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==Overview==
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__TOC__
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The enzyme cytochrome c nitrite reductase catalyses the six-electron reduction of nitrite to ammonia as one of the key steps in the biological nitrogen cycle, where it participates in the anaerobic energy metabolism of dissimilatory nitrate ammonification. Here we report on the crystal structure of this enzyme from the microorganism Sulfurospirillum deleyianum, which we solved by multiwavelength anomalous dispersion methods. We propose a reaction scheme for the transformation of nitrite based on structural and spectroscopic information. Cytochrome c nitrite reductase is a functional dimer, with 10 close-packed haem groups of type c and an unusual lysine-coordinated high-spin haem at the active site. By comparing the haem arrangement of this nitrite reductase with that of other multihaem cytochromes, we have been able to identify a family of proteins in which the orientation of haem groups is conserved whereas structure and function are not.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1QDB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfurospirillum_deleyianum Sulfurospirillum deleyianum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDB OCA].
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==Reference==
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Structure of cytochrome c nitrite reductase., Einsle O, Messerschmidt A, Stach P, Bourenkov GP, Bartunik HD, Huber R, Kroneck PM, Nature. 1999 Jul 29;400(6743):476-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10440380 10440380]
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[[Category: Single protein]]
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[[Category: Sulfurospirillum deleyianum]]
[[Category: Sulfurospirillum deleyianum]]
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[[Category: Einsle, O.]]
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[[Category: Einsle O]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Kroneck, P M.H.]]
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[[Category: Kroneck PMH]]
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[[Category: Messerschmidt, A.]]
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[[Category: Messerschmidt A]]
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[[Category: Stach, P.]]
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[[Category: Stach P]]
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[[Category: CA]]
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[[Category: HEM]]
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[[Category: SO4]]
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[[Category: c-type cytochrome lysine-coordinated heme nitrite reductase]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:10 2008''
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Current revision

CYTOCHROME C NITRITE REDUCTASE

PDB ID 1qdb

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