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1qn4
From Proteopedia
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| - | [[Image:1qn4.png|left|200px]] | ||
| - | + | ==Crystal structure of the T(-24) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.== | |
| - | + | <StructureSection load='1qn4' size='340' side='right'caption='[[1qn4]], [[Resolution|resolution]] 1.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1qn4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QN4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qn4 OCA], [https://pdbe.org/1qn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1qn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qn4 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qn4_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qn4 ConSurf]. |
| - | [[1qn4]] is a 6 chain structure | + | <div style="clear:both"></div> |
==See Also== | ==See Also== | ||
| - | *[[TATA- | + | *[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]] |
| - | + | *[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
| - | [[Category: Burley | + | [[Category: Large Structures]] |
| - | [[Category: Kim | + | [[Category: Burley SK]] |
| - | [[Category: Kodadek | + | [[Category: Kim JL]] |
| - | [[Category: Patikoglou | + | [[Category: Kodadek T]] |
| - | [[Category: Sun | + | [[Category: Patikoglou GA]] |
| - | [[Category: Yang | + | [[Category: Sun L]] |
| - | + | [[Category: Yang S-H]] | |
Current revision
Crystal structure of the T(-24) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
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