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1qns

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[[Image:1qns.png|left|200px]]
 
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{{STRUCTURE_1qns| PDB=1qns | SCENE= }}
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==The 3-D structure of a Trichoderma reesei b-mannanase from glycoside hydrolase family 5==
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<StructureSection load='1qns' size='340' side='right'caption='[[1qns]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qns]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qns OCA], [https://pdbe.org/1qns PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qns RCSB], [https://www.ebi.ac.uk/pdbsum/1qns PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qns ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MANA_HYPJR MANA_HYPJR] Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and ivory nut mannan, releasing mainly tri- and disaccharides (PubMed:7793911, Ref.3, Ref.4, PubMed:8529653). Also has transglycosylation activity. Transglycosylation of two mannotrioses into a mannohexaose is the major transglycosylation route (PubMed:8529653, Ref.7, PubMed:24950755).<ref>PMID:24950755</ref> <ref>PMID:7793911</ref> <ref>PMID:8529653</ref> [PROSITE-ProRule:PRU00597][SAM:MobiDB-lite]<ref>PMID:24950755</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qns_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qns ConSurf].
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<div style="clear:both"></div>
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===THE 3-D STRUCTURE OF A TRICHODERMA REESEI B-MANNANASE FROM GLYCOSIDE HYDROLASE FAMILY 5===
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==See Also==
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*[[Mannosidase 3D structures|Mannosidase 3D structures]]
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{{ABSTRACT_PUBMED_10666621}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1qns]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNS OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:010666621</ref><references group="xtra"/>
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[[Category: Mannan endo-1,4-beta-mannosidase]]
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[[Category: Trichoderma reesei]]
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[[Category: Murshudov, G.]]
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[[Category: Penttila, M.]]
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[[Category: Sabini, E.]]
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[[Category: Schubert, H.]]
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[[Category: Siika-Aho, M.]]
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[[Category: Wilson, K S.]]
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[[Category: Anomalous scattering]]
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[[Category: Hydrolase]]
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[[Category: Mannanase]]
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[[Category: Trichoderma reesei]]
[[Category: Trichoderma reesei]]
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[[Category: Murshudov G]]
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[[Category: Penttila M]]
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[[Category: Sabini E]]
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[[Category: Schubert H]]
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[[Category: Siika-Aho M]]
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[[Category: Wilson KS]]

Current revision

The 3-D structure of a Trichoderma reesei b-mannanase from glycoside hydrolase family 5

PDB ID 1qns

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