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1qs8

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[[Image:1qs8.png|left|200px]]
 
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{{STRUCTURE_1qs8| PDB=1qs8 | SCENE= }}
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==Crystal structure of the P. vivax aspartic proteinase plasmepsin complexed with the inhibitor pepstatin A==
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<StructureSection load='1qs8' size='340' side='right'caption='[[1qs8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of the P. vivax aspartic proteinase plasmepsin complexed with the inhibitor pepstatin A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qs8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QS8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12767832}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qs8 OCA], [https://pdbe.org/1qs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qs8 RCSB], [https://www.ebi.ac.uk/pdbsum/1qs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qs8 ProSAT]</span></td></tr>
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[[1qs8]] is a 4 chain structure of [[Plasmepsin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QS8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O60989_PLAVI O60989_PLAVI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/1qs8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qs8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Plasmepsin|Plasmepsin]]
*[[Plasmepsin|Plasmepsin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012767832</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
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[[Category: Bernstein, N Khazanovich.]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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[[Category: Cherney, M M.]]
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[[Category: Cherney MM]]
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[[Category: Dame, J B.]]
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[[Category: Dame JB]]
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[[Category: James, M N.G.]]
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[[Category: James MNG]]
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[[Category: Yowell, C A.]]
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[[Category: Khazanovich Bernstein N]]
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[[Category: Aspartic proteinase]]
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[[Category: Yowell CA]]
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[[Category: Haemoglobinase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Malaria]]
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[[Category: Pepstatin some]]
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[[Category: Plasmepsin]]
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Current revision

Crystal structure of the P. vivax aspartic proteinase plasmepsin complexed with the inhibitor pepstatin A

PDB ID 1qs8

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OCA

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