This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qun

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1qun" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qun, resolution 2.8&Aring;" /> '''X-RAY STRUCTURE OF TH...)
Current revision (06:07, 17 April 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qun.gif|left|200px]]<br /><applet load="1qun" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1qun, resolution 2.8&Aring;" />
 
-
'''X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI'''<br />
 
-
==Overview==
+
==X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI==
-
Type 1 pili-adhesive fibers expressed in most members of the, Enterobacteriaceae family-mediate binding to mannose receptors on host, cells through the FimH adhesin. Pilus biogenesis proceeds by way of the, chaperone/usher pathway. The x-ray structure of the FimC-FimH, chaperone-adhesin complex from uropathogenic Escherichia coli at 2.5, angstrom resolution reveals the basis for carbohydrate recognition and for, pilus assembly. The carboxyl-terminal pilin domain of FimH has an, immunoglobulin-like fold, except that the seventh strand is missing, leaving part of the hydrophobic core exposed. A donor strand, complementation mechanism in which the chaperone donates a strand to, complete the pilin domain explains the basis for both chaperone function, and pilus biogenesis.
+
<StructureSection load='1qun' size='340' side='right'caption='[[1qun]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1qun]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QUN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qun OCA], [https://pdbe.org/1qun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qun RCSB], [https://www.ebi.ac.uk/pdbsum/1qun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qun ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FIMC_ECOLI FIMC_ECOLI] Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1qun_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qun ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1QUN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QUN OCA].
+
*[[Adhesin 3D structures|Adhesin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli., Choudhury D, Thompson A, Stojanoff V, Langermann S, Pinkner J, Hultgren SJ, Knight SD, Science. 1999 Aug 13;285(5430):1061-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10446051 10446051]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Choudhury, D.]]
+
[[Category: Choudhury D]]
-
[[Category: Hultgren, S.J.]]
+
[[Category: Hultgren SJ]]
-
[[Category: Knight, S.]]
+
[[Category: Knight S]]
-
[[Category: Langerman, S.]]
+
[[Category: Langerman S]]
-
[[Category: Pinkner, J.]]
+
[[Category: Pinkner J]]
-
[[Category: Stojanoff, V.]]
+
[[Category: Stojanoff V]]
-
[[Category: Thompson, A.]]
+
[[Category: Thompson A]]
-
[[Category: chaperone adhesin donor strand complementation]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:00:17 2007''
+

Current revision

X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI

PDB ID 1qun

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qun"
Personal tools