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1qvn
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1qvn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qvn, resolution 2.70Å" /> '''Structure of SP4160...) |
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| - | [[Image:1qvn.gif|left|200px]]<br /> | ||
| - | <applet load="1qvn" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1qvn, resolution 2.70Å" /> | ||
| - | '''Structure of SP4160 Bound to IL-2 V69A'''<br /> | ||
| - | == | + | ==Structure of SP4160 Bound to IL-2 V69A== |
| - | + | <StructureSection load='1qvn' size='340' side='right'caption='[[1qvn]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1qvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRI:2-GUANIDINO-4-METHYL-PENTANOIC+ACID+[2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE'>FRI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvn OCA], [https://pdbe.org/1qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvn RCSB], [https://www.ebi.ac.uk/pdbsum/1qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/1qvn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qvn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Delano | + | [[Category: Delano WL]] |
| - | [[Category: Thanos | + | [[Category: Thanos CD]] |
| - | [[Category: Wells | + | [[Category: Wells JA]] |
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Current revision
Structure of SP4160 Bound to IL-2 V69A
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