This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qvz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1qvz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qvz, resolution 1.85&Aring;" /> '''Crystal structure of...)
Current revision (06:07, 17 April 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qvz.jpg|left|200px]]<br /><applet load="1qvz" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1qvz, resolution 1.85&Aring;" />
 
-
'''Crystal structure of the S. cerevisiae YDR533c protein'''<br />
 
-
==Overview==
+
==Crystal structure of the S. cerevisiae YDR533c protein==
-
The ORF YDR533c from Saccharomyces cerevisiae codes for a 25.5 kDa protein, of unknown biochemical function. Transcriptome analysis of yeast has shown, that this gene is activated in response to various stress conditions, together with proteins belonging to the heat shock family. In order to, clarify its biochemical function, we determined the crystal structure of, YDR533c to 1.85 A resolution by the single anomalous diffraction method., The protein possesses an alpha/beta hydrolase fold and a putative, Cys-His-Glu catalytic triad common to a large enzyme family containing, proteases, amidotransferases, lipases, and esterases. The protein has, strong structural resemblance with the E. coli Hsp31 protein and the, intracellular protease I from Pyrococcus horikoshii, which are considered, class I and class III members of the Hsp31 family, respectively. Detailed, structural analysis strongly suggests that the YDR533c protein crystal, structure is the first one of a class II member of the Hsp31 family.
+
<StructureSection load='1qvz' size='340' side='right'caption='[[1qvz]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1qvz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVZ FirstGlance]. <br>
-
1QVZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QVZ OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvz OCA], [https://pdbe.org/1qvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvz RCSB], [https://www.ebi.ac.uk/pdbsum/1qvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvz ProSAT]</span></td></tr>
-
Crystal structure of the YDR533c S. cerevisiae protein, a class II member of the Hsp31 family., Graille M, Quevillon-Cheruel S, Leulliot N, Zhou CZ, de la Sierra Gallay IL, Jacquamet L, Ferrer JL, Liger D, Poupon A, Janin J, van Tilbeurgh H, Structure. 2004 May;12(5):839-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15130476 15130476]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HSP31_YEAST HSP31_YEAST] Probable protease. May act as a chaperone.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/1qvz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qvz ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Graille M]]
-
[[Category: Graille, M.]]
+
[[Category: Leulliot N]]
-
[[Category: Leulliot, N.]]
+
[[Category: Quevillon-Cheruel S]]
-
[[Category: Quevillon-Cheruel, S.]]
+
[[Category: Van Tilbeurgh H]]
-
[[Category: Tilbeurgh, H.van.]]
+
-
[[Category: alpha/beta hydrolase fold]]
+
-
[[Category: catalytic triad]]
+
-
[[Category: heat shock protein]]
+
-
[[Category: structural genomics]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:02:51 2007''
+

Current revision

Crystal structure of the S. cerevisiae YDR533c protein

PDB ID 1qvz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qvz"
Personal tools