This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r4p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1r4p" [edit=sysop:move=sysop])
Current revision (06:09, 17 April 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1r4p.png|left|200px]]
 
-
{{STRUCTURE_1r4p| PDB=1r4p | SCENE= }}
+
==Shiga toxin type 2==
-
 
+
<StructureSection load='1r4p' size='340' side='right'caption='[[1r4p]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-
===Shiga toxin type 2===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1r4p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R4P FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_15075327}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4p OCA], [https://pdbe.org/1r4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r4p RCSB], [https://www.ebi.ac.uk/pdbsum/1r4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r4p ProSAT]</span></td></tr>
-
[[1r4p]] is a 6 chain structure of [[Shiga toxin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4P OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/STXA_BP933 STXA_BP933] The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r4p_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r4p ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Shiga toxin|Shiga toxin]]
+
*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:015075327</ref><references group="xtra"/>
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: RRNA N-glycosylase]]
+
[[Category: Large Structures]]
-
[[Category: Brien, A D.O.]]
+
[[Category: Cherney MM]]
-
[[Category: Cherney, M M.]]
+
[[Category: Fraser ME]]
-
[[Category: Fraser, M E.]]
+
[[Category: Fujinaga M]]
-
[[Category: Fujinaga, M.]]
+
[[Category: James MNG]]
-
[[Category: James, M N.G.]]
+
[[Category: Melton-Celsa AR]]
-
[[Category: Melton-Celsa, A R.]]
+
[[Category: O'Brien AD]]
-
[[Category: Twiddy, E M.]]
+
[[Category: Twiddy EM]]
-
[[Category: Ab5 toxin]]
+
-
[[Category: Toxin]]
+

Current revision

Shiga toxin type 2

PDB ID 1r4p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r4p"
Personal tools