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1r4p

From Proteopedia

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{{Seed}}
 
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[[Image:1r4p.png|left|200px]]
 
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<!--
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==Shiga toxin type 2==
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The line below this paragraph, containing "STRUCTURE_1r4p", creates the "Structure Box" on the page.
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<StructureSection load='1r4p' size='340' side='right'caption='[[1r4p]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r4p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R4P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1r4p| PDB=1r4p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4p OCA], [https://pdbe.org/1r4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r4p RCSB], [https://www.ebi.ac.uk/pdbsum/1r4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r4p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STXA_BP933 STXA_BP933] The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r4p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r4p ConSurf].
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<div style="clear:both"></div>
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===Shiga toxin type 2===
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==See Also==
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*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15075327}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15075327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15075327}}
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==About this Structure==
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1R4P is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4P OCA].
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==Reference==
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<ref group="xtra">PMID:15075327</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Large Structures]]
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[[Category: Brien, A D.O.]]
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[[Category: Cherney MM]]
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[[Category: Cherney, M M.]]
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[[Category: Fraser ME]]
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[[Category: Fraser, M E.]]
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[[Category: Fujinaga M]]
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[[Category: Fujinaga, M.]]
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[[Category: James MNG]]
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[[Category: James, M N.G.]]
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[[Category: Melton-Celsa AR]]
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[[Category: Melton-Celsa, A R.]]
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[[Category: O'Brien AD]]
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[[Category: Twiddy, E M.]]
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[[Category: Twiddy EM]]
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[[Category: Ab5 toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:06:24 2009''
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Current revision

Shiga toxin type 2

PDB ID 1r4p

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