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1r54

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[[Image:1r54.png|left|200px]]
 
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{{STRUCTURE_1r54| PDB=1r54 | SCENE= }}
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==Crystal structure of the catalytic domain of human ADAM33==
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<StructureSection load='1r54' size='340' side='right'caption='[[1r54]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal structure of the catalytic domain of human ADAM33===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R54 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14659745}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r54 OCA], [https://pdbe.org/1r54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r54 RCSB], [https://www.ebi.ac.uk/pdbsum/1r54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r54 ProSAT]</span></td></tr>
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[[1r54]] is a 1 chain structure of [[A Disintegrin And Metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R54 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN] Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA) [MIM:[https://omim.org/entry/600807 600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.<ref>PMID:12110844</ref> <ref>PMID:16773130</ref> <ref>PMID:19237393</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r54_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r54 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]]
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014659745</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hammond, G.]]
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[[Category: Large Structures]]
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[[Category: Mirza, U A.]]
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[[Category: Hammond G]]
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[[Category: Orth, P.]]
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[[Category: Mirza UA]]
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[[Category: Prosise, W W.]]
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[[Category: Orth P]]
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[[Category: Reicher, P.]]
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[[Category: Prosise WW]]
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[[Category: Strickland, C.]]
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[[Category: Reicher P]]
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[[Category: Taremi, S S.]]
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[[Category: Strickland C]]
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[[Category: Wang, W.]]
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[[Category: Taremi SS]]
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[[Category: Xiao, L.]]
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[[Category: Wang W]]
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[[Category: Yarosh-Tomaine, T.]]
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[[Category: Xiao L]]
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[[Category: Zou, J.]]
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[[Category: Yarosh-Tomaine T]]
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[[Category: Adam]]
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[[Category: Zou J]]
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[[Category: Asthma]]
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[[Category: Hydrolase]]
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[[Category: Metalloprotease]]
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Current revision

Crystal structure of the catalytic domain of human ADAM33

PDB ID 1r54

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