This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r54

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:09, 17 April 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1r54.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the catalytic domain of human ADAM33==
-
The line below this paragraph, containing "STRUCTURE_1r54", creates the "Structure Box" on the page.
+
<StructureSection load='1r54' size='340' side='right'caption='[[1r54]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1r54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R54 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1r54| PDB=1r54 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r54 OCA], [https://pdbe.org/1r54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r54 RCSB], [https://www.ebi.ac.uk/pdbsum/1r54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r54 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN] Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA) [MIM:[https://omim.org/entry/600807 600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.<ref>PMID:12110844</ref> <ref>PMID:16773130</ref> <ref>PMID:19237393</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r54_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r54 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of the catalytic domain of human ADAM33'''
+
==See Also==
-
 
+
*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1R54 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R54 OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14659745 14659745]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hammond, G.]]
+
[[Category: Hammond G]]
-
[[Category: Mirza, U A.]]
+
[[Category: Mirza UA]]
-
[[Category: Orth, P.]]
+
[[Category: Orth P]]
-
[[Category: Prosise, W W.]]
+
[[Category: Prosise WW]]
-
[[Category: Reicher, P.]]
+
[[Category: Reicher P]]
-
[[Category: Strickland, C.]]
+
[[Category: Strickland C]]
-
[[Category: Taremi, S S.]]
+
[[Category: Taremi SS]]
-
[[Category: Wang, W.]]
+
[[Category: Wang W]]
-
[[Category: Xiao, L.]]
+
[[Category: Xiao L]]
-
[[Category: Yarosh-Tomaine, T.]]
+
[[Category: Yarosh-Tomaine T]]
-
[[Category: Zou, J.]]
+
[[Category: Zou J]]
-
[[Category: Adam]]
+
-
[[Category: Asthma]]
+
-
[[Category: Metalloprotease]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:23 2008''
+

Current revision

Crystal structure of the catalytic domain of human ADAM33

PDB ID 1r54

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r54"
Personal tools