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1r6u

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{{STRUCTURE_1r6u| PDB=1r6u | SCENE= }}
 
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===Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity===
 
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{{ABSTRACT_PUBMED_17637340}}
 
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==Function==
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==Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity==
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[[http://www.uniprot.org/uniprot/SYWC_HUMAN SYWC_HUMAN]] Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.<ref>PMID:11773626</ref> <ref>PMID:1373391</ref> <ref>PMID:11773625</ref> <ref>PMID:14630953</ref>
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<StructureSection load='1r6u' size='340' side='right'caption='[[1r6u]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1r6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6U FirstGlance]. <br>
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[[1r6u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TYM:TRYPTOPHANYL-5AMP'>TYM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6u OCA], [https://pdbe.org/1r6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6u RCSB], [https://www.ebi.ac.uk/pdbsum/1r6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYWC_HUMAN SYWC_HUMAN] Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.<ref>PMID:11773626</ref> <ref>PMID:1373391</ref> <ref>PMID:11773625</ref> <ref>PMID:14630953</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6u ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017637340</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tryptophan--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: McRee, D E.]]
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[[Category: McRee DE]]
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[[Category: Otero, F J.]]
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[[Category: Otero FJ]]
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[[Category: Pouplana, L Ribas de.]]
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[[Category: Ribas de Pouplana L]]
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[[Category: Schimmel, P.]]
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[[Category: Schimmel P]]
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[[Category: Skene, R J.]]
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[[Category: Skene RJ]]
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[[Category: Yang, X L.]]
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[[Category: Yang X-L]]
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[[Category: Anticodon recognition domain]]
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[[Category: Bound trp-amp]]
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[[Category: Class ic trna synthetase]]
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[[Category: Ligase]]
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[[Category: Rossmann fold catalytic domain]]
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Current revision

Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity

PDB ID 1r6u

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