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TRNA methyltransferase 3D structures

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[TRNA methyltransferase]]
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[TRNA methyltransferase]]
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*'''tRNA to N1 of guanine methyltransferase'''
 +
 +
**[[6w14]] – MsTrm – ''Mycobacterium smegmatis''<br />
 +
**[[6w15]] – MsTrm + SAH <br />
 +
**[[7kff]] – CdTrm – ''Corynebacterium diphtheriae''<br />
 +
**[[3knu]], [[8sh4]] – ApTrm – ''Anaplasma phagocytophilum''<br />
*'''tRNA guanine 9 N1 methyltransferase'''
*'''tRNA guanine 9 N1 methyltransferase'''
Line 10: Line 17:
**[[4jwj]] – yTrm + SAH – yeast<br />
**[[4jwj]] – yTrm + SAH – yeast<br />
-
*'''tRNA guanine 37 N1 methyltransferase'''
+
*'''tRNA guanine 37 N1 methyltransferase or TrmD'''
-
**[[3knu]], [[6uev]] – ApTrm – ''Anaplasma phagocytophilum'' <br />
 
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
**[[3ief]] – Trm – ''Bartonella henselae'' <br />
**[[3ief]] – Trm – ''Bartonella henselae'' <br />
**[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br />
**[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br />
-
**[[3ky7]] – Trm – ''Staphylococcus aureus''<br />
+
**[[3ky7]] – SaTrm – ''Staphylococcus aureus''<br />
-
**[[3quv]], [[6nvr]] – MaTrm – ''Mycobacterium abscessus''<br />
+
**[[3quv]], [[6nvr]], [[7rey]] – MaTrmD – ''Mycobacterium abscessus''<br />
**[[5hjj]], [[5yac]] – PabTrm – ''Pyrococcus abyssi''<br />
**[[5hjj]], [[5yac]] – PabTrm – ''Pyrococcus abyssi''<br />
-
**[[6jki]] – PaTrm – ''Pseudomonas aeruginosa''<br />
+
**[[6jki]] – PaTrmD – ''Pseudomonas aeruginosa''<br />
**[[5zhi]] – MtTrm – ''Mycobacterium tuberculosis''<br />
**[[5zhi]] – MtTrm – ''Mycobacterium tuberculosis''<br />
 +
**[[7myq]] – AbTrm – ''Acinetobacter baumannii'' <br />
*Complexes of tRNA guanine 37 N1 methyltransferase
*Complexes of tRNA guanine 37 N1 methyltransferase
-
**[[1uak]], [[4yvg]] – HiTrm + SAM <br />
+
**[[1uak]], [[4yvg]] – HiTrmD + SAM <br />
**[[1ual]], [[1uam]] – HiTrm + SAH <br />
**[[1ual]], [[1uam]] – HiTrm + SAH <br />
-
**[[3axz]] – HiTrm + adenosine<br />
+
**[[3axz]] – HiTrmD + adenosine<br />
-
**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br />
+
**[[4mcb]], [[4mcc]], [[4mcd]] – HiTrmD + inhibitor<br />
-
**[[4yvh]] – HiTrm + SFG <br />
+
**[[4yvh]] – HiTrmD + SFG <br />
-
**[[4yvi]], [[4yvj]], [[4yvk]] – HiTrm + SFG + tRNA<br />
+
**[[4yvi]], [[4yvj]], [[4yvk]] – HiTrmD + SFG + tRNA<br />
-
**[[5d9f]], [[4ypw]], [[4ypx]], [[4ypy]], [[4ypz]], [[4yq0]], [[4yq1]], [[4yq2]], [[4yq3]], [[4yq4]], [[4yq5]], [[4yq6]], [[4yq7]], [[4yq8]], [[4yq9]], [[4yqa]], [[4yqb]], [[4yqc]], [[4yqg]], [[4yqi]], [[4yqj]], [[4yqk]], [[4yql]], [[4yqn]], [[4yqo]], [[4yqp]], [[4yqq]], [[4yqr]], [[4yqs]], [[4yqt]], [[4yqd]] – HiTrm + SAM competitive<br />
+
**[[5d9f]], [[4ypw]], [[4ypx]], [[4ypy]], [[4ypz]], [[4yq0]], [[4yq1]], [[4yq2]], [[4yq3]], [[4yq4]], [[4yq5]], [[4yq6]], [[4yq7]], [[4yq8]], [[4yq9]], [[4yqa]], [[4yqb]], [[4yqc]], [[4yqg]], [[4yqi]], [[4yqj]], [[4yqk]], [[4yql]], [[4yqn]], [[4yqo]], [[4yqp]], [[4yqq]], [[4yqr]], [[4yqs]], [[4yqt]], [[4yqd]] – HiTrmD + SAM competitive<br />
**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
**[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br />
-
**[[3ay0]] – MjTrm + adenosine<br />
+
**[[3ay0]] – MjTrm5 + adenosine<br />
**[[4h3y]], [[4h3z]] – Trm + SAH – ''Burkholderia phymatum'' <br />
**[[4h3y]], [[4h3z]] – Trm + SAH – ''Burkholderia phymatum'' <br />
**[[4ig6]] – ApTrm + SAH <br />
**[[4ig6]] – ApTrm + SAH <br />
Line 40: Line 47:
**[[5hji]], [[5hjm]] – PabTrm + adenosine derivative<br />
**[[5hji]], [[5hjm]] – PabTrm + adenosine derivative<br />
**[[5hjk]] – PabTrm + SAH <br />
**[[5hjk]] – PabTrm + SAH <br />
-
**[[6qo2]], [[6qo3]], [[6qo4]], [[6qo6]], [[6qoa]], [[6qoc]], [[6qod]], [[6qoe]], [[6qof]], [[6qog]], [[6qoh]], [[6qoi]], [[6qoj]], [[6qok]], [[6qol]], [[6qom]], [[6qon]], [[6qoo]], [[6qop]], [[6qoq]], [[6qor]], [[6qos]], [[6qot]], [[6qou]], [[6qov]], [[6qow]], [[6qox]], [[6qqq]], [[6qqr]], [[6qqt]], [[6qqu]], [[6qqv]], [[6qqw]], [[6qqz]], [[6qr0]], [[6qr1]], [[6qr2]], [[6qr3]], [[6qr4]], [[6qr7]], [[6qr9]], [[6qra]], [[6qrc]], [[6qrd]], [[6qre]], [[6qrf]], [[6qrg]] – MaTrm + inhibitor<br />
+
**[[6qo2]], [[6qo3]], [[6qo4]], [[6qo6]], [[6qoa]], [[6qoc]], [[6qod]], [[6qoe]], [[6qof]], [[6qog]], [[6qoh]], [[6qoi]], [[6qoj]], [[6qok]], [[6qol]], [[6qom]], [[6qon]], [[6qoo]], [[6qop]], [[6qoq]], [[6qor]], [[6qos]], [[6qot]], [[6qou]], [[6qov]], [[6qow]], [[6qox]], [[6qqq]], [[6qqr]], [[6qqt]], [[6qqu]], [[6qqv]], [[6qqw]], [[6qqz]], [[6qr0]], [[6qr1]], [[6qr2]], [[6qr3]], [[6qr4]], [[6qr7]], [[6qr9]], [[6qra]], [[6qrc]], [[6qrd]], [[6qre]], [[6qrf]], [[6qrg]] – MaTrmD + inhibitor<br />
-
**[[6nw6]] – MaTrm + SAM <br />
+
**[[6nw6]] – MaTrmD + SAM <br />
-
**[[6nw7]] – MaTrm + SAH <br />
+
**[[6nw7]], [[7rez]], [[7rf0]] – MaTrmD + SAH <br />
-
**[[6joe]], [[6jof]], [[5zhm]], [[5zhn]], [[6afk]] – PaTrm + inhibitor<br />
+
**[[6joe]], [[6jof]], [[5zhm]], [[5zhn]], [[6afk]] – PaTrmD + inhibitor<br />
-
**[[6wyq]] – PaTrm + SAM <br />
+
**[[6wyq]] – PaTrmD + SAM <br />
-
**[[6wyr]] – PaTrm + SFG <br />
+
**[[6wyr]] – PaTrmD + SFG <br />
-
**[[5zhj]] – MtTrm + SAH <br />
+
**[[5zhj]] – MtTrmD + SAH <br />
**[[5zhk]], [[5zhl]] – MtTrm + inhibitor<br />
**[[5zhk]], [[5zhl]] – MtTrm + inhibitor<br />
-
**[[5wt1]] – PabTrm + tRNA + SAH <br />
+
**[[5wt1]] – PabTrm5a + tRNA + SAH <br />
-
**[[5wt3]] – PabTrm + tRNA + methylthioadenosine<br />
+
**[[5hji]] – PabTrm5a + adenosine<br />
 +
**[[5wt3]] – PabTrm5a + tRNA + methylthioadenosine<br />
 +
**[[7mys]] – AbTrmD + SAH <br />
 +
**[[7kff]] – CdTrmD + SAH <br />
*'''tRNA guanine 46 N7 methyltransferase'''
*'''tRNA guanine 46 N7 methyltransferase'''
-
**[[2vdu]], [[2vdv]] – yTrm <br />
+
**[[2vdu]], [[2vdv]] – yTrm8 <br />
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
-
**[[2fca]] – BsTrm – ''Bacillus subtilis'' <br />
+
**[[2fca]], [[7nzj]] – BsTrmB – ''Bacillus subtilis'' <br />
-
**[[3dxx]] – EcTrm <br />
+
**[[3dxx]] – EcTrmB <br />
*Complexes of tRNA guanine 46 N7 methyltransferase
*Complexes of tRNA guanine 46 N7 methyltransferase
**[[3ckk]] – hTrm + SAM - human<br />
**[[3ckk]] – hTrm + SAM - human<br />
-
**[[3dxy]] – EcTrm + SAM <br />
+
**[[7pl1]] – hTrm + sinefungin<br />
-
**[[3dxz]] – EcTrm + SAH <br />
+
**[[7ogj]] – hTrm + SAH <br />
 +
**[[3dxy]] – EcTrmB + SAM <br />
 +
**[[3dxz]] – EcTrmB + SAH <br />
 +
**[[7nyb]] – BsTrmD + SAM <br />
 +
**[[7nzi]] – BsTrmD + SAH<br />
 +
 
 +
*Trm to O2 of guanosine 18
 +
 
 +
**[[7edc]] – EcTrmH (mutant) + SAM<br />
*Trm to O2 of cytidine 32
*Trm to O2 of cytidine 32
-
**[[4cnd]] – EcTrm (mutant)<br />
+
**[[4cnd]] – EcTrmJ (mutant)<br />
-
**[[4xbo]] – EcTrm + SAH<br />
+
**[[4xbo]] – EcTrmJ + SAH<br />
-
**[[4cne]] – EcTrm (mutant) + SAH<br />
+
**[[4cne]] – EcTrmJ (mutant) + SAH<br />
-
*'''tRNA cytidine 34 O2 methyltransferase'''
+
*'''tRNA cytidine 34 O2 methyltransferase YibK'''
-
**[[6jp6]] – yTrm <br />
+
**[[6jp6]] – yTrm7 <br />
-
**[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br />
+
**[[3e5y]] – BpTrmH – ''Burkholderia pseudomalllei'' <br />
-
**[[4jak]], [[4kdz]] – EcTrm <br />
+
**[[4jak]], [[4kdz]] – EcTrmL <br />
-
**[[6qkv]] – PaTrm <br />
+
**[[7e3s]] – TrmL – ''Shewanella oneidensis<''br />
 +
**[[7e3r]] – VvTrmL – ''Vibrio vulnificus''<br />
 +
**[[1j85]], [[6ahw]], [[7d51]] – HiYibK<br />
 +
**[[6qkv]], [[6qh8]] – PaYibK <br />
**[[6ahw]] – HiTrm <br />
**[[6ahw]] – HiTrm <br />
*Complexes of tRNA cytidine 34 O2 methyltransferase
*Complexes of tRNA cytidine 34 O2 methyltransferase
-
**[[6jpl]] – yTrm + SAM <br />
+
**[[6jpl]] – yTrm7 + SAM <br />
**[[4kgn]] – BpTrm + SAH <br />
**[[4kgn]] – BpTrm + SAH <br />
**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
-
**[[4jal]] – EcTrm + SAH<br />
+
**[[4jal]] – EcYibK + SAH<br />
 +
**[[7e3q]] – VvTrm + SAH <br />
-
Trm to C5 of cytidine 38
+
*Trm to C5 of cytidine 38
**[[6fdf]] – fyTrm + SAH <br />
**[[6fdf]] – fyTrm + SAH <br />
-
Trm to O2 of cytidine/uridine
+
*Trm to O2 of cytidine/uridine
-
**[[5gra]] – Trm – ''Zymomonas mobilis'' <br />
+
**[[5gra]] – TrmJ – ''Zymomonas mobilis'' <br />
-
**[[5gmc]], [[5gmb]] – PaTrm <b />
+
**[[5gmc]], [[5gmb]] – PaTrmJ <b />
-
**[[5gm8]] – PaTrm + SFG<br />
+
**[[5gm8]] – PaTrmJ + SFG<br />
*'''tRNA guanine 6 N2 methyltransferase'''
*'''tRNA guanine 6 N2 methyltransferase'''
-
**[[3tm5]] – PfTrm + SFG – ''Pyrococcvus furiosus''<br />
+
**[[3tm5]] – PfTrm14 + SFG – ''Pyrococcvus furiosus''<br />
-
**[[3tlj]] – PfTrm + SAH<br />
+
**[[3tlj]] – PfTrm14 + SAH<br />
-
**[[3tm4]] – PfTrm + SAM<br />
+
**[[3tm4]] – PfTrm14 + SAM<br />
 +
 
 +
*Trm to N2 of guanine 10
 +
 
 +
**[[6zxy]] – AfTrm11 – ''Archaeoglobus fulgidus''<br />
 +
**[[6zxv]], [[6zxw]] – AfTrm11 + SFG<br />
*Trm M2G/M22G10
*Trm M2G/M22G10
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**[[6q56]] – BsTrm (mutant)<br />
**[[6q56]] – BsTrm (mutant)<br />
-
**[[6qe6]] – BsTrm + SAH<br />
+
**[[6qe6]] – TrmK + SAH - ''Mycoplasma capricolum''<br />
 +
**[[7o4m]] – SaTrm <br />
 +
**[[7o4o]] – SaTrm + SAH<br />
 +
**[[7o4n]] – SaTrm + SAM<br />
*'''tRNA adenine 58 N1 methyltransferase'''
*'''tRNA adenine 58 N1 methyltransferase'''
Line 123: Line 153:
**[[5ccb]], [[5cd1]] – hTrm + SAH + tRNA-Lys<br />
**[[5ccb]], [[5cd1]] – hTrm + SAH + tRNA-Lys<br />
**[[5ccx]] – hTrm + tRNA-Lys<br />
**[[5ccx]] – hTrm + tRNA-Lys<br />
-
**[[5eqj]] – yTrm <br />
+
**[[5eqj]] – yTrm6 <br />
-
**[[5erg]] – yTrm + SAM<br />
+
**[[5erg]] – yTrm6 + SAM<br />
**[[2pwy]] – TtTrm – ''Thermus thermophilus''<br />
**[[2pwy]] – TtTrm – ''Thermus thermophilus''<br />
**[[5c0o]], [[5c1i]] – TtTrm (mutant) + SAM<br />
**[[5c0o]], [[5c1i]] – TtTrm (mutant) + SAM<br />
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*'''tRNA uracil 54 methyltransferase'''
*'''tRNA uracil 54 methyltransferase'''
-
**[[3bt7]] – yTrm + RNA<br />
+
**[[3bt7]] – yTrmA + RNA<br />
*Trm9-TRM112
*Trm9-TRM112
Line 143: Line 173:
*Trm dual specificity
*Trm dual specificity
-
**[[4pl1]], [[4pl2]] – EcTrm (mutant) + SAM<br />
+
**[[4pl1]], [[4pl2]] – EcTrm Rlmn (mutant) + SAM<br />
-
**[[6ems]], [[6emt]] – TkTrm <br />
+
**[[5hr7]], [[5hr6]] – EcTrm RlmN (mutant) + tRNA-Glu<br />
-
**[[6emu]] – TkTrm + SAM<br />
+
 
-
**[[6emv]] –TkTrm + SAH<br />
+
*Trm10 dual specificity to N1 of adenine 9/guanine 9
 +
 
 +
**[[7onu]] – hTrm10 in RNase P complex – Cryo EM<br />
 +
**[[6ems]], [[6emt]] – TkTrm10 (mutant)<br />
 +
**[[6emv]] – TkTrm10 (mutant) + SAH<br />
 +
**[[6emu]] – TkTrm10 (mutant) + SAM<br />
 +
 
 +
*METTL6
 +
 
 +
**[[7f1e]] – hMETTL6 + SAM<br />
 +
**[[7ezg]] – hMETTL6 + SAH<br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of tRNA methyltransferase

Updated on 17-April-2024 - For a general description of the protein see TRNA methyltransferase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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