User:Lily Lindemann/Sandbox1

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='''Glucagon-Like Peptide 1 Receptor (GLP1-R)'''=
='''Glucagon-Like Peptide 1 Receptor (GLP1-R)'''=
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== Introduction ==
 
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<StructureSection load='6X18' size='340' side='right' caption='GLP bound to the receptor' scene='10/1038821/Receptor/1'>
 
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Glucagon-Like Peptide 1 Receptor or GLP1-R uses the glucagon-like peptide to signal the body to secrete insulin and inhibit glucagon secretion. When glucose levels in the blood rise (usually after consuming food), GLP-1R activates, creating a signaling cascade to signal cAMP. After the signaling cascade, the final result is the secretion of insulin to the rest of the body. Discovered in 1990s while trying to understand the mechanism of GLP-1 action. [https://www.biochempeg.com/article/299.html#:~:text=In%20the%201970s%2C%20the%20first,(Figure%201)%20were%20unraveled] The structure was determined using cryogenic electron microscopy.
 
[[Image:GLP Body Effect Graphic.png|400 px|right|]]
[[Image:GLP Body Effect Graphic.png|400 px|right|]]
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== Function ==
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== Introduction and Function ==
[[Image:GLP1.png|400 px|right|thumb|Pathway of Insulin Secretion through GLP-1 Receptor]]
[[Image:GLP1.png|400 px|right|thumb|Pathway of Insulin Secretion through GLP-1 Receptor]]
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<StructureSection load='6X18' size='340' side='right' caption='GLP bound to the receptor' scene='10/1038821/Receptor/1'>
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GLP-1R works in conjunction with GIP-R to maintain blood glucose levels after the ingestion of food.
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Glucagon-Like Peptide 1 Receptor or GLP1-R uses the glucagon-like peptide to signal the body to secrete insulin and inhibit glucagon secretion. When glucose levels in the blood rise (usually after consuming food), GLP-1R activates, creating a signaling cascade to signal cAMP. After the signaling cascade, the final result is the secretion of insulin to the rest of the body. Discovered in 1990s while trying to understand the mechanism of GLP-1 action. [https://www.biochempeg.com/article/299.html#:~:text=In%20the%201970s%2C%20the%20first,(Figure%201)%20were%20unraveled] The structure was determined using cryogenic electron microscopy.
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It is imperative for these receptors to work well so diseases like diabetes and obesity do not ensue.
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Revision as of 14:05, 18 April 2024

Glucagon-Like Peptide 1 Receptor (GLP1-R)




Introduction and Function

Pathway of Insulin Secretion through GLP-1 Receptor
Pathway of Insulin Secretion through GLP-1 Receptor

GLP bound to the receptor

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Lily Lindemann

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