This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Integrator complex
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Function == | == Function == | ||
| - | '''Integrator complex''' (Int) is a protein complex which induces termination at loci transcribed by RNA polymerase II. Multiple Int subunits coordinate effective termination<ref>PMID:36634676</ref>. | + | '''Integrator complex''' (Int) is a protein complex which induces termination at loci transcribed by RNA polymerase II. Multiple Int subunits coordinate effective termination<ref>PMID:36634676</ref>. Int consists of 14 subunits some of which act as RNA endonuclease and are essential for small nuclear RNA biogenesis<ref>PMID:32800671</ref> |
== Disease == | == Disease == | ||
Revision as of 10:07, 24 April 2024
| |||||||||||
References
- ↑ Wagner EJ, Tong L, Adelman K. Integrator is a global promoter-proximal termination complex. Mol Cell. 2023 Feb 2;83(3):416-427. PMID:36634676 doi:10.1016/j.molcel.2022.11.012
- ↑ Mendoza-Figueroa MS, Tatomer DC, Wilusz JE. The Integrator Complex in Transcription and Development. Trends Biochem Sci. 2020 Nov;45(11):923-934. PMID:32800671 doi:10.1016/j.tibs.2020.07.004
