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8smn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state== | |
| - | + | <StructureSection load='8smn' size='340' side='right'caption='[[8smn]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8smn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SMN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8smn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8smn OCA], [https://pdbe.org/8smn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8smn RCSB], [https://www.ebi.ac.uk/pdbsum/8smn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8smn ProSAT]</span></td></tr> |
| - | [[Category: Gorniak | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HYAS1_XENLA HYAS1_XENLA] Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.<ref>PMID:3410156</ref> <ref>PMID:9442026</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Gorniak I]] | ||
| + | [[Category: Zimmer J]] | ||
Current revision
Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state
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