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8u87
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8u87 is ON HOLD Authors: Chenxi, C., Meiqin, J., Ji, S. Description: Structural Basis of Human NOX5 Activation Category: Unreleased Structures ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural Basis of Human NOX5 Activation== | |
| - | + | <StructureSection load='8u87' size='340' side='right'caption='[[8u87]], [[Resolution|resolution]] 3.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8u87]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U87 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEB:HEME+B/C'>HEB</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u87 OCA], [https://pdbe.org/8u87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u87 RCSB], [https://www.ebi.ac.uk/pdbsum/8u87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u87 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NOX5_HUMAN NOX5_HUMAN] Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.<ref>PMID:11483596</ref> <ref>PMID:12686516</ref> <ref>PMID:17275676</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chenxi C]] | ||
| + | [[Category: Ji S]] | ||
| + | [[Category: Meiqin J]] | ||
Current revision
Structural Basis of Human NOX5 Activation
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