1tob

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[[Image:1tob.jpg|left|200px]]
 
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==SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1tob", creates the "Structure Box" on the page.
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<StructureSection load='1tob' size='340' side='right'caption='[[1tob]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TOA:3-DEOXY-3-AMINO+GLUCOSE'>TOA</scene>, <scene name='pdbligand=TOB:1,3-DIAMINO-5,6-DIHYDROXYCYCLOHEXANE'>TOB</scene>, <scene name='pdbligand=TOC:2,3,6-TRIDEOXY-2,6-DIAMINO+GLUCOSE'>TOC</scene></td></tr>
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{{STRUCTURE_1tob| PDB=1tob | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tob OCA], [https://pdbe.org/1tob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tob RCSB], [https://www.ebi.ac.uk/pdbsum/1tob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tob ProSAT]</span></td></tr>
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</table>
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'''SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Synthetic construct]]
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BACKGROUND: Aminoglycoside antibiotics are known to target ribosomal, retroviral and catalytic RNAs with high affinity and specificity. Recently, in vitro selection experiments have identified RNA aptamers that bind to aminoglycoside antibiotics with nanomolar affinity and stringent specificity, allowing discrimination between closely related family members. There has, to date, been limited structural information on the molecular basis of such saccharide-RNA recognition. RESULTS: We describe a solution-structure determination of the tobramycin-RNA aptamer complex, obtained using NMR and molecular dynamics. The structure gives insight into the molecular features associated with saccharide-RNA recognition. Tobramycin adopts a defined alignment and binds to the RNA major groove centered about a stem-loop junction site. A portion of the bound tobramycin is encapsulated between the floor of the major groove and a looped-out cytosine residue that forms a flap over the binding site in the complex. CONCLUSIONS: The emergence of antibiotic-resistant pathogens and their impact on human health continues to be a major concern in the medical community. Rational modification of existing antibiotics aimed at improving their efficacy requires a molecular view of their receptor-binding sites. We have provided such a molecular view for a member of the aminoglycoside antibiotic family that targets RNA.
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[[Category: Fiala R]]
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[[Category: Jiang L]]
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==About this Structure==
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[[Category: Patel DJ]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOB OCA].
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[[Category: Suri AK]]
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==Reference==
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Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex., Jiang L, Suri AK, Fiala R, Patel DJ, Chem Biol. 1997 Jan;4(1):35-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9070426 9070426]
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[[Category: Fiala, R.]]
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[[Category: Jiang, L.]]
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[[Category: Patel, D J.]]
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[[Category: Suri, A K.]]
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[[Category: Ribonucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:10:59 2008''
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Current revision

SACCHARIDE-RNA RECOGNITION IN AN AMINOGLYCOSIDE ANTIBIOTIC-RNA APTAMER COMPLEX, NMR, 7 STRUCTURES

PDB ID 1tob

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