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1x95

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{{Seed}}
 
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[[Image:1x95.png|left|200px]]
 
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==Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)==
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The line below this paragraph, containing "STRUCTURE_1x95", creates the "Structure Box" on the page.
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<StructureSection load='1x95' size='340' side='right'caption='[[1x95]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x95]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X95 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XR2:1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM'>XR2</scene></td></tr>
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{{STRUCTURE_1x95| PDB=1x95 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x95 OCA], [https://pdbe.org/1x95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x95 RCSB], [https://www.ebi.ac.uk/pdbsum/1x95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x95 ProSAT]</span></td></tr>
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</table>
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===solution structure of the B-DNA hexamer ATGCAT complexed with MLN944, a bisphenazine anticancer drug===
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Dai J]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15317822}}, adds the Publication Abstract to the page
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[[Category: Mistry P]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15317822 is the PubMed ID number.
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[[Category: Ooi AT]]
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[[Category: Punchihewa C]]
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{{ABSTRACT_PUBMED_15317822}}
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[[Category: Yang D]]
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==About this Structure==
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X95 OCA].
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==Reference==
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Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug., Dai J, Punchihewa C, Mistry P, Ooi AT, Yang D, J Biol Chem. 2004 Oct 29;279(44):46096-103. Epub 2004 Aug 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317822 15317822]
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[[Category: Dai, J.]]
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[[Category: Mistry, P.]]
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[[Category: Ooi, A T.]]
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[[Category: Punchihewa, C.]]
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[[Category: Yang, D.]]
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[[Category: Anticancer drug]]
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[[Category: Ap-1]]
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[[Category: Mln944]]
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[[Category: Nmr]]
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[[Category: Novel dna binding]]
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[[Category: Structure]]
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[[Category: Transcription inhibition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:53:27 2008''
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Current revision

Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)

PDB ID 1x95

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