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2arw

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[[Image:2arw.gif|left|200px]]<br /><applet load="2arw" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2arw" />
 
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'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''<br />
 
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==Overview==
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==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor==
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The members of the interleukin-6-type family of cytokines interact with, receptors that have a modular structure and are built of several, immunoglobulin-like and fibronectin type III-like domains. These receptors, have a characteristic cytokine receptor homology region consisting of two, fibronectin type III-like domains defined by a set of four conserved, cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On, target cells, interleukin-6 (IL-6) initially binds to its cognate, alpha-receptor and subsequently to a homodimer of the signal transducer, receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular, domains. The N-terminal immunoglobulin-like domain is not involved in, ligand binding, whereas the third membrane-proximal fibronectin-like, domain (IL-6R-D3) accounts for more than 90% of the binding energy to, IL-6. Here, we present the solution structure of the IL-6R-D3 domain, solved by multidimensional heteronuclear NMR spectroscopy.
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<StructureSection load='2arw' size='340' side='right'caption='[[2arw]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [https://pdbe.org/2arw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [https://www.ebi.ac.uk/pdbsum/2arw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2arw ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2ARW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA].
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16972794 16972794]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dingley, A.J.]]
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[[Category: Dingley AJ]]
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[[Category: Grotzinger, J.]]
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[[Category: Grotzinger J]]
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[[Category: Hecht, O.]]
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[[Category: Hecht O]]
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[[Category: Ozbek, S.]]
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[[Category: Ozbek S]]
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[[Category: Rose-John, S.]]
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[[Category: Rose-John S]]
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[[Category: Schwantner, A.]]
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[[Category: Schwantner A]]
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[[Category: fibronectin-type iii like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:14:47 2008''
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Current revision

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

PDB ID 2arw

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