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2arw

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The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

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Retrieved from "http://52.214.119.220/wiki/index.php/2arw"

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-[[Image:2arw.gif|left|200px]]<br />
-<applet load="2arw" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2arw" />
-'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''<br />
-==Overview==
+==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor==
-The members of the interleukin-6-type family of cytokines interact with, receptors that have a modular structure and are built of several, immunoglobulin-like and fibronectin type III-like domains. These receptors, have a characteristic cytokine receptor homology region consisting of two, fibronectin type III-like domains defined by a set of four conserved, cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On, target cells, interleukin-6 (IL-6) initially binds to its cognate, alpha-receptor and subsequently to a homodimer of the signal transducer, receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular, domains. The N-terminal immunoglobulin-like domain is not involved in, ligand binding, whereas the third membrane-proximal fibronectin-like, domain (IL-6R-D3) accounts for more than 90% of the binding energy to, IL-6. Here, we present the solution structure of the IL-6R-D3 domain, solved by multidimensional heteronuclear NMR spectroscopy.
+<StructureSection load='2arw' size='340' side='right'caption='[[2arw]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [https://pdbe.org/2arw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [https://www.ebi.ac.uk/pdbsum/2arw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>   Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2arw ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-ARW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA].
+*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16972794 16972794]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Dingley, A.J.]]
+[[Category: Dingley AJ]]
-[[Category: Grotzinger, J.]]
+[[Category: Grotzinger J]]
-[[Category: Hecht, O.]]
+[[Category: Hecht O]]
-[[Category: Ozbek, S.]]
+[[Category: Ozbek S]]
-[[Category: Rose-John, S.]]
+[[Category: Rose-John S]]
-[[Category: Schwantner, A.]]
+[[Category: Schwantner A]]
-[[Category: fibronectin-type iii like]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:54:06 2007''

2arw

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The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

Structural highlights

Function

Evolutionary Conservation

See Also

References

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