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2bc8

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{{Seed}}
 
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[[Image:2bc8.png|left|200px]]
 
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==[Sec2,3,8,12]-ImI==
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The line below this paragraph, containing "STRUCTURE_2bc8", creates the "Structure Box" on the page.
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<StructureSection load='2bc8' size='340' side='right'caption='[[2bc8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BC8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc8 OCA], [https://pdbe.org/2bc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc8 ProSAT]</span></td></tr>
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{{STRUCTURE_2bc8| PDB=2bc8 | SCENE= }}
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</table>
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== Function ==
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===[Sec2,3,8,12]-ImI===
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[https://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16500898 is the PubMed ID number.
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[[Category: Conus imperialis]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16500898}}
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[[Category: Armishaw CJ]]
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==About this Structure==
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2BC8 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC8 OCA].
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==Reference==
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Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists., Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF, J Biol Chem. 2006 May 19;281(20):14136-43. Epub 2006 Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16500898 16500898]
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[[Category: Single protein]]
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[[Category: Armishaw, C J.]]
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[[Category: Conotoxin]]
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[[Category: Diselenide bond]]
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[[Category: Disulfide bond]]
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[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:50:38 2008''
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Current revision

[Sec2,3,8,12]-ImI

PDB ID 2bc8

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