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2cia

From Proteopedia

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{{Seed}}
 
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[[Image:2cia.png|left|200px]]
 
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==human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec==
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The line below this paragraph, containing "STRUCTURE_2cia", creates the "Structure Box" on the page.
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<StructureSection load='2cia' size='340' side='right'caption='[[2cia]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_2cia| PDB=2cia | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cia OCA], [https://pdbe.org/2cia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cia RCSB], [https://www.ebi.ac.uk/pdbsum/2cia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cia ProSAT]</span></td></tr>
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</table>
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===HUMAN NCK2 SH2-DOMAIN IN COMPLEX WITH A DECAPHOSPHOPEPTIDE FROM TRANSLOCATED INTIMIN RECEPTOR (TIR) OF EPEC===
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== Function ==
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[https://www.uniprot.org/uniprot/NCK2_HUMAN NCK2_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16636066}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16636066 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cia_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16636066}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2CIA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIA OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cia ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains., Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW, J Biol Chem. 2006 Jun 30;281(26):18236-45. Epub 2006 Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16636066 16636066]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Findeis, A C.]]
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[[Category: Findeis AC]]
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[[Category: Frese, S.]]
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[[Category: Frese S]]
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[[Category: Heinz, D W.]]
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[[Category: Heinz DW]]
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[[Category: Marquardt, T.]]
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[[Category: Marquardt T]]
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[[Category: Roske, Y S.]]
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[[Category: Roske YS]]
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[[Category: Schubert, W D.]]
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[[Category: Schubert W-D]]
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[[Category: Stradal, T E.B.]]
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[[Category: Stradal TEB]]
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[[Category: Binding specificity]]
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[[Category: Phosphorylation]]
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[[Category: Sh2-domain]]
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[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:43:35 2008''
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Current revision

human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec

PDB ID 2cia

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