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2f40

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[[Image:2f40.gif|left|200px]]
 
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{{Structure
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==Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction==
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|PDB= 2f40 |SIZE=350|CAPTION= <scene name='initialview01'>2f40</scene>
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<StructureSection load='2f40' size='340' side='right'caption='[[2f40]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2f40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F40 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f40 OCA], [https://pdbe.org/2f40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f40 RCSB], [https://www.ebi.ac.uk/pdbsum/2f40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f40 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction'''
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[https://www.uniprot.org/uniprot/Q8U0X6_PYRFU Q8U0X6_PYRFU]
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__TOC__
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</StructureSection>
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==Overview==
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[[Category: Large Structures]]
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Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: Bansal S]]
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==About this Structure==
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[[Category: Prestegard JH]]
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2F40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F40 OCA].
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==Reference==
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Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16927360 16927360]
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[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Bansal, S.]]
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[[Category: Prestegard, J H.]]
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[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
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[[Category: protein structure initiative]]
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[[Category: protein structure prediction]]
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[[Category: psi]]
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[[Category: pyrococcus furious]]
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[[Category: residual dipolar coupling]]
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[[Category: secsg]]
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[[Category: simulated annealing]]
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[[Category: southeast collaboratory for structural genomic]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:49 2008''
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Current revision

Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction

PDB ID 2f40

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