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2fyh

From Proteopedia

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[[Image:2fyh.jpg|left|200px]]
 
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==Solution structure of the 2'-5' RNA ligase-like protein from Pyrococcus furiosus==
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The line below this paragraph, containing "STRUCTURE_2fyh", creates the "Structure Box" on the page.
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<StructureSection load='2fyh' size='340' side='right'caption='[[2fyh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FYH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyh OCA], [https://pdbe.org/2fyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fyh RCSB], [https://www.ebi.ac.uk/pdbsum/2fyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyh ProSAT], [https://www.topsan.org/Proteins/RSGI/2fyh TOPSAN]</span></td></tr>
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{{STRUCTURE_2fyh| PDB=2fyh | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of the 2'-5' RNA ligase-like protein from Pyrococcus furiosus'''
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[https://www.uniprot.org/uniprot/THPR_PYRFU THPR_PYRFU] Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity.<ref>PMID:19155324</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2FYH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYH OCA].
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<jmolCheckbox>
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[[Category: Pyrococcus furiosus]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyh_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Kanai, A.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Kawai, G.]]
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</jmolCheckbox>
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[[Category: Matsuda, T.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fyh ConSurf].
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[[Category: Muto, Y.]]
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<div style="clear:both"></div>
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[[Category: Okada, K.]]
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== References ==
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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<references/>
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[[Category: Sakamoto, T.]]
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__TOC__
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[[Category: Yokoyama, S.]]
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</StructureSection>
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[[Category: 2'-5' rna ligase-like protein]]
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[[Category: Large Structures]]
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[[Category: Hxtx motif]]
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[[Category: Pyrococcus furiosus DSM 3638]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Kanai A]]
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[[Category: Nmr]]
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[[Category: Kawai G]]
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[[Category: Nppsfa]]
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[[Category: Matsuda T]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Muto Y]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Okada K]]
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[[Category: Rsgi]]
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[[Category: Sakamoto T]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:27:04 2008''
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Current revision

Solution structure of the 2'-5' RNA ligase-like protein from Pyrococcus furiosus

PDB ID 2fyh

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