2jkb

==CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE NANB IN COMPLEX WITH 2,7-ANHYDRO-NEU5AC==

<StructureSection load='2jkb' size='340' side='right' caption='[[2jkb]], [[Resolution|resolution]] 1.54&Aring;' scene=''>

<table><tr><td colspan='2'>[[2jkb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JKB FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SKD:2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC+ACID'>SKD</scene><br>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vw0|2vw0]], [[2vw1|2vw1]], [[2vw2|2vw2]]</td></tr>

<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anhydrosialidase Anhydrosialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.15 4.2.2.15] </span></td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jkb RCSB], [http://www.ebi.ac.uk/pdbsum/2jkb PDBsum]</span></td></tr>

<table>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkb_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

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== Publication Abstract from PubMed ==

The human pathogen Streptococcus pneumoniae expresses neuraminidase proteins that cleave sialic acids from complex carbohydrates. The pneumococcus genome encodes up to three neuraminidase proteins that have been shown to be important virulence factors. Here, we report the first structure of a neuraminidase from S. pneumoniae: the crystal structure of NanB in complex with its reaction product 2,7-anhydro-Neu5Ac. Our structural data, together with biochemical analysis, establish NanB as an intramolecular trans-sialidase with strict specificity towards alpha2-3 linked sialic acid substrates. In addition, we show that NanB differs in its substrate specificity from the other pneumococcal neuraminidase NanA.

Structural and functional studies of Streptococcus pneumoniae neuraminidase B: An intramolecular trans-sialidase.,Gut H, King SJ, Walsh MA FEBS Lett. 2008 Oct 15;582(23-24):3348-52. Epub 2008 Sep 5. PMID:18775704<ref>PMID:18775704</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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*[[Neuraminidase|Neuraminidase]]

[[Category: Anhydrosialidase]]

[[Category: Streptococcus pneumoniae]]

[[Category: Gut, H.]]

[[Category: King, S J.]]

[[Category: Walsh, M A.]]

[[Category: Neuraminidase]]