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2k0u

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==High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct==
==High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct==
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<StructureSection load='2k0u' size='340' side='right' caption='[[2k0u]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2k0u' size='340' side='right'caption='[[2k0u]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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[[2k0u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0U OCA]. <br>
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<table><tr><td colspan='2'>[[2k0u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K0U FirstGlance]. <br>
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<b>Related:</b> [[2k0t|2k0t]], [[2k0v|2k0v]], [[2k0w|2k0w]]<br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PT:CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II)'>1PT</scene></td></tr>
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== Publication Abstract from PubMed ==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k0u OCA], [https://pdbe.org/2k0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k0u RCSB], [https://www.ebi.ac.uk/pdbsum/2k0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k0u ProSAT]</span></td></tr>
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The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of damage-recognition proteins that control downstream effects of the adducts. Here we report a comprehensive comparison of the structural distortion of DNA caused by CP and OX adducts in the TGGT sequence context using nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulations. When compared to our previous studies in other sequence contexts, these structural studies help us understand the effect of the sequence context on the conformation of Pt-GG DNA adducts. We find that both the sequence context and the type of Pt-GG DNA adduct (CP vs. OX) play an important role in the conformation and the conformational dynamics of Pt-DNA adducts, possibly explaining their influence on the ability of many damage-recognition proteins to bind to Pt-DNA adducts.
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</table>
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Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links.,Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King CL, Baskerville-Abraham I, Boysen G, Swenberg JA, Campbell SL, Dokholyan NV, Chaney SG PLoS One. 2011;6(8):e23582. Epub 2011 Aug 10. PMID:21853154<ref>PMID:21853154</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bhattacharyya, D.]]
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[[Category: Large Structures]]
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[[Category: Campbell, S L.]]
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[[Category: Bhattacharyya D]]
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[[Category: Chaney, S G.]]
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[[Category: Campbell SL]]
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[[Category: King, C L.]]
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[[Category: Chaney SG]]
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[[Category: Dna]]
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[[Category: King CL]]
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[[Category: Oxaliplatin-dna adduct]]
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High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct

PDB ID 2k0u

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