We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2k7f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:44, 1 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2k7f.jpg|left|200px]]
 
-
<!--
+
==HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA==
-
The line below this paragraph, containing "STRUCTURE_2k7f", creates the "Structure Box" on the page.
+
<StructureSection load='2k7f' size='340' side='right'caption='[[2k7f]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2k7f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7F FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7f OCA], [https://pdbe.org/2k7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7f RCSB], [https://www.ebi.ac.uk/pdbsum/2k7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7f ProSAT]</span></td></tr>
-
{{STRUCTURE_2k7f| PDB=2k7f | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA===
+
[https://www.uniprot.org/uniprot/RFC1_HUMAN RFC1_HUMAN] The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.<ref>PMID:8999859</ref> Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.<ref>PMID:8999859</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
2K7F is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7F OCA].
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/2k7f_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k7f ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ab, E.]]
+
[[Category: Large Structures]]
-
[[Category: Bonvin, A.]]
+
[[Category: Ab E]]
-
[[Category: Kobayashi, M.]]
+
[[Category: Bonvin A]]
-
[[Category: Siegal, G.]]
+
[[Category: Kobayashi M]]
-
[[Category: Activator]]
+
[[Category: Siegal G]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Brct]]
+
-
[[Category: Complex]]
+
-
[[Category: Dna]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Domain]]
+
-
[[Category: Haddock]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Model]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Protein]]
+
-
[[Category: Replication/dna complex]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Zinc]]
+
-
[[Category: Zinc-finger]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:33:10 2009''
+

Current revision

HADDOCK calculated model of the complex between the BRCT region of RFC p140 and dsDNA

PDB ID 2k7f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2k7f"
Personal tools