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2kax
From Proteopedia
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| - | [[Image:2kax.png|left|200px]] | ||
| - | + | ==Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound states== | |
| + | <StructureSection load='2kax' size='340' side='right'caption='[[2kax]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kax]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kax OCA], [https://pdbe.org/2kax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kax RCSB], [https://www.ebi.ac.uk/pdbsum/2kax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kax ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S10A5_HUMAN S10A5_HUMAN] Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.<ref>PMID:10882717</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/2kax_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kax ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[S100 proteins 3D structures|S100 proteins 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
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| - | == | + | |
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bertini | + | [[Category: Large Structures]] |
| - | [[Category: Gupta | + | [[Category: Bertini I]] |
| - | [[Category: Hu | + | [[Category: Das Gupta S]] |
| - | [[Category: Karavelas | + | [[Category: Hu X]] |
| - | [[Category: Luchinat | + | [[Category: Karavelas T]] |
| - | [[Category: Parigi | + | [[Category: Luchinat C]] |
| - | + | [[Category: Parigi G]] | |
| - | [[Category: Yuan | + | [[Category: Yuan J]] |
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Current revision
Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound states
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Categories: Homo sapiens | Large Structures | Bertini I | Das Gupta S | Hu X | Karavelas T | Luchinat C | Parigi G | Yuan J
