This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2kay
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Large structure}} | ||
| - | {{STRUCTURE_2kay| PDB=2kay | SCENE= }} | ||
| - | ===Solution structure and dynamics of S100A5 in the Ca2+ -bound states=== | ||
| - | {{ABSTRACT_PUBMED_19536568}} | ||
| - | == | + | ==Solution structure and dynamics of S100A5 in the Ca2+ -bound states== |
| - | [[2kay]] is a 2 chain structure with sequence from [ | + | <StructureSection load='2kay' size='340' side='right'caption='[[2kay]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kay]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kay OCA], [https://pdbe.org/2kay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kay RCSB], [https://www.ebi.ac.uk/pdbsum/2kay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kay ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S10A5_HUMAN S10A5_HUMAN] Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.<ref>PMID:10882717</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/2kay_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kay ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[S100 proteins 3D structures|S100 proteins 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bertini | + | [[Category: Large Structures]] |
| - | [[Category: Gupta | + | [[Category: Bertini I]] |
| - | [[Category: Hu | + | [[Category: Das Gupta S]] |
| - | [[Category: Karavelas | + | [[Category: Hu X]] |
| - | [[Category: Luchinat | + | [[Category: Karavelas T]] |
| - | [[Category: Parigi | + | [[Category: Luchinat C]] |
| - | + | [[Category: Parigi G]] | |
| - | [[Category: Yuan | + | [[Category: Yuan J]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure and dynamics of S100A5 in the Ca2+ -bound states
| |||||||||||
Categories: Homo sapiens | Large Structures | Bertini I | Das Gupta S | Hu X | Karavelas T | Luchinat C | Parigi G | Yuan J
