2kim
From Proteopedia
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| - | [[Image:2kim.png|left|200px]] | ||
| - | + | ==1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.== | |
| - | + | <StructureSection load='2kim' size='340' side='right'caption='[[2kim]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_AQ3810 Vibrio parahaemolyticus AQ3810]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kim OCA], [https://pdbe.org/2kim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kim RCSB], [https://www.ebi.ac.uk/pdbsum/2kim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kim ProSAT], [https://www.topsan.org/Proteins/NESGC/2kim TOPSAN]</span></td></tr> |
| - | [[2kim]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATL_VIBPQ ATL_VIBPQ] Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2]<ref>PMID:20212037</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/2kim_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kim ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA methyltransferase|DNA methyltransferase]] | + | *[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]] |
| - | [[Category: Vibrio parahaemolyticus | + | == References == |
| - | [[Category: Acton | + | <references/> |
| - | [[Category: Aramini | + | __TOC__ |
| - | [[Category: Belote | + | </StructureSection> |
| - | [[Category: Ciccosanti | + | [[Category: Large Structures]] |
| - | [[Category: Everett | + | [[Category: Vibrio parahaemolyticus AQ3810]] |
| - | [[Category: Jiang | + | [[Category: Acton TB]] |
| - | [[Category: Montelione | + | [[Category: Aramini JM]] |
| - | + | [[Category: Belote RL]] | |
| - | [[Category: Nair | + | [[Category: Ciccosanti CT]] |
| - | [[Category: Rost | + | [[Category: Everett JK]] |
| - | [[Category: Swapna | + | [[Category: Jiang M]] |
| - | [[Category: Xiao | + | [[Category: Montelione GT]] |
| - | + | [[Category: Nair R]] | |
| - | + | [[Category: Rost B]] | |
| - | + | [[Category: Swapna GVT]] | |
| - | + | [[Category: Xiao R]] | |
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Current revision
1.7-mm microcryoprobe solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.
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