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2kqe

From Proteopedia

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[[Image:2kqe.png|left|200px]]
 
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{{STRUCTURE_2kqe| PDB=2kqe | SCENE= }}
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==Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine==
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<StructureSection load='2kqe' size='340' side='right'caption='[[2kqe]]' scene=''>
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===Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20098424}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=RIB:RIBOSE'>RIB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqe OCA], [https://pdbe.org/2kqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqe RCSB], [https://www.ebi.ac.uk/pdbsum/2kqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqe ProSAT]</span></td></tr>
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[[2kqe]] is a 1 chain structure of [[Apurinic/Apyrimidinic Endonuclease-1]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQE OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APLF_HUMAN APLF_HUMAN] Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<ref>PMID:17396150</ref> <ref>PMID:17353262</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/2kqe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kqe ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Apurinic/Apyrimidinic Endonuclease-1|Apurinic/Apyrimidinic Endonuclease-1]]
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020098424</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brockmann, C.]]
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[[Category: Large Structures]]
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[[Category: Eustermann, S.]]
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[[Category: Brockmann C]]
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[[Category: Neuhaus, D.]]
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[[Category: Eustermann S]]
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[[Category: Yang, J.]]
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[[Category: Neuhaus D]]
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[[Category: Adp-ribosylation]]
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[[Category: Yang J]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Zinc-finger]]
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Current revision

Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine

PDB ID 2kqe

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