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2kw3

From Proteopedia

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{{Seed}}
 
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[[Image:2kw3.jpg|left|200px]]
 
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<!--
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==Heterotrimeric interaction between RFX5 and RFXAP==
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The line below this paragraph, containing "STRUCTURE_2kw3", creates the "Structure Box" on the page.
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<StructureSection load='2kw3' size='340' side='right'caption='[[2kw3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KW3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw3 OCA], [https://pdbe.org/2kw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kw3 ProSAT]</span></td></tr>
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{{STRUCTURE_2kw3| PDB=2kw3 | SCENE= }}
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</table>
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== Disease ==
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===Heterotrimeric interaction between RFX5 and RFXAP===
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[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN] Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
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==About this Structure==
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== Evolutionary Conservation ==
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2KW3 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/2kw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kw3 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boss, J M.]]
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[[Category: Large Structures]]
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[[Category: Briggs, L L.]]
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[[Category: Boss JM]]
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[[Category: Garvie, C W.]]
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[[Category: Briggs LL]]
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[[Category: Laird, K M.]]
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[[Category: Garvie CW]]
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[[Category: Summers, M F.]]
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[[Category: Laird KM]]
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[[Category: Dna binding protein]]
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[[Category: Summers MF]]
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[[Category: Enhanceosome]]
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[[Category: Mhcii]]
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[[Category: Rfx5]]
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[[Category: Rfxap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:46:22 2010''
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Current revision

Heterotrimeric interaction between RFX5 and RFXAP

PDB ID 2kw3

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