2kzt

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'''Unreleased structure'''
 
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The entry 2kzt is ON HOLD until Paper Publication
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==Structure of the Tandem MA-3 Region of Pdcd4==
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<StructureSection load='2kzt' size='340' side='right'caption='[[2kzt]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzt OCA], [https://pdbe.org/2kzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzt RCSB], [https://www.ebi.ac.uk/pdbsum/2kzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
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Authors: Waters, L.C., Strong, S.L., Oka, O., Muskett, F.W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A.J., Klempnauer, K., Carr, M.D.
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==See Also==
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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Description: Structure of the Tandem MA-3 Region of Pdcd4
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:15:05 2010''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Banerjee S]]
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[[Category: Carr MD]]
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[[Category: Henry AJ]]
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[[Category: Klempnauer KH]]
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[[Category: Muskett FW]]
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[[Category: Oka O]]
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[[Category: Schmedt T]]
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[[Category: Strong SL]]
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[[Category: Veverka V]]
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[[Category: Waters LC]]

Current revision

Structure of the Tandem MA-3 Region of Pdcd4

PDB ID 2kzt

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