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2l0b

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Current revision (06:50, 1 May 2024) (edit) (undo)
 
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==Solution NMR structure of zinc finger domain of E3 ubiquitin-protein ligase praja-1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR4710B==
==Solution NMR structure of zinc finger domain of E3 ubiquitin-protein ligase praja-1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR4710B==
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<StructureSection load='2l0b' size='340' side='right'caption='[[2l0b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l0b' size='340' side='right'caption='[[2l0b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PJA1, RNF70 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0b OCA], [https://pdbe.org/2l0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0b RCSB], [https://www.ebi.ac.uk/pdbsum/2l0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0b OCA], [https://pdbe.org/2l0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0b RCSB], [https://www.ebi.ac.uk/pdbsum/2l0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PJA1_HUMAN PJA1_HUMAN]] Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.<ref>PMID:12036302</ref>
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[https://www.uniprot.org/uniprot/PJA1_HUMAN PJA1_HUMAN] Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.<ref>PMID:12036302</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti, C]]
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[[Category: Ciccosanti C]]
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[[Category: Everett, J K]]
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[[Category: Everett JK]]
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[[Category: Hamilton, K]]
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[[Category: Hamilton K]]
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[[Category: Liu, G]]
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[[Category: Liu G]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Shastry R]]
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[[Category: Shastry, R]]
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[[Category: Tong S]]
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[[Category: Tong, S]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Ligase]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Zinc finger]]
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Current revision

Solution NMR structure of zinc finger domain of E3 ubiquitin-protein ligase praja-1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR4710B

PDB ID 2l0b

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