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2l0e

From Proteopedia

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[[Image:2l0e.png|left|200px]]
 
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{{STRUCTURE_2l0e| PDB=2l0e | SCENE= }}
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==Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger==
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<StructureSection load='2l0e' size='340' side='right'caption='[[2l0e]]' scene=''>
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===Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20843797}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0e OCA], [https://pdbe.org/2l0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0e RCSB], [https://www.ebi.ac.uk/pdbsum/2l0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0e ProSAT]</span></td></tr>
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[[2l0e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0E OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>
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<ref group="xtra">PMID:020843797</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Fliegel, L.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Lee, B L.]]
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Check<jmol>
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[[Category: Sykes, B D.]]
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<jmolCheckbox>
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[[Category: Tzeng, J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0e_consurf.spt"</scriptWhenChecked>
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[[Category: Membrane protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Nhe1]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Transmembrane helix]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0e ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fliegel L]]
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[[Category: Lee BL]]
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[[Category: Sykes BD]]
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[[Category: Tzeng J]]

Current revision

Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger

PDB ID 2l0e

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