2l0j

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[[Image:2l0j.png|left|200px]]
 
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==Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer==
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The line below this paragraph, containing "STRUCTURE_2l0j", creates the "Structure Box" on the page.
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<StructureSection load='2l0j' size='340' side='right'caption='[[2l0j]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l0j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Udorn/307/1972(H3N2)) Influenza A virus (A/Udorn/307/1972(H3N2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0j OCA], [https://pdbe.org/2l0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0j RCSB], [https://www.ebi.ac.uk/pdbsum/2l0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0j ProSAT]</span></td></tr>
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{{STRUCTURE_2l0j| PDB=2l0j | SCENE= }}
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</table>
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== Function ==
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===Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer===
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[https://www.uniprot.org/uniprot/M2_I72A2 M2_I72A2] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).<ref>PMID:7508997</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 20966252 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20966252}}
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==About this Structure==
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[[2l0j]] is a 4 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0J OCA].
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==See Also==
==See Also==
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*[[Ion channels (Part II)]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[M2 protein|M2 protein]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:20966252</ref><references group="xtra"/>
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<references/>
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[[Category: Influenza a virus]]
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__TOC__
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[[Category: Busath, D D.]]
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</StructureSection>
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[[Category: Cross, T A.]]
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[[Category: Large Structures]]
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[[Category: Dong, H.]]
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[[Category: Busath DD]]
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[[Category: Peterson, E.]]
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[[Category: Cross TA]]
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[[Category: Qin, H.]]
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[[Category: Dong H]]
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[[Category: Sharma, M.]]
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[[Category: Peterson E]]
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[[Category: Yi, M.]]
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[[Category: Qin H]]
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[[Category: Zhou, H X.]]
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[[Category: Sharma M]]
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[[Category: Conductance domain]]
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[[Category: Yi M]]
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[[Category: Influenza]]
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[[Category: Zhou HX]]
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[[Category: Lipid bilayer]]
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[[Category: M2 proton channel]]
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[[Category: Membrane domain]]
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[[Category: Solid state nmr]]
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[[Category: Transport protein]]
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[[Category: Viral protein]]
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Current revision

Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer

PDB ID 2l0j

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