2l0j
From Proteopedia
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| - | [[Image:2l0j.png|left|200px]] | ||
| - | + | ==Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer== | |
| - | + | <StructureSection load='2l0j' size='340' side='right'caption='[[2l0j]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2l0j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Udorn/307/1972(H3N2)) Influenza A virus (A/Udorn/307/1972(H3N2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0j OCA], [https://pdbe.org/2l0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0j RCSB], [https://www.ebi.ac.uk/pdbsum/2l0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0j ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2l0j]] is a 4 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/M2_I72A2 M2_I72A2] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).<ref>PMID:7508997</ref> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Ion channels 3D structures|Ion channels 3D structures]] | |
| - | *[[Ion channels|Ion channels]] | + | |
*[[M2 protein|M2 protein]] | *[[M2 protein|M2 protein]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Busath | + | [[Category: Large Structures]] |
| - | [[Category: Cross | + | [[Category: Busath DD]] |
| - | [[Category: Dong | + | [[Category: Cross TA]] |
| - | [[Category: Peterson | + | [[Category: Dong H]] |
| - | [[Category: Qin | + | [[Category: Peterson E]] |
| - | [[Category: Sharma | + | [[Category: Qin H]] |
| - | [[Category: Yi | + | [[Category: Sharma M]] |
| - | [[Category: Zhou | + | [[Category: Yi M]] |
| - | + | [[Category: Zhou HX]] | |
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Current revision
Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer
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Categories: Large Structures | Busath DD | Cross TA | Dong H | Peterson E | Qin H | Sharma M | Yi M | Zhou HX
