This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2l14

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:51, 1 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2l14.png|left|200px]]
 
-
<!--
+
==Structure of CBP nuclear coactivator binding domain in complex with p53 TAD==
-
The line below this paragraph, containing "STRUCTURE_2l14", creates the "Structure Box" on the page.
+
<StructureSection load='2l14' size='340' side='right'caption='[[2l14]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2l14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L14 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l14 OCA], [https://pdbe.org/2l14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l14 RCSB], [https://www.ebi.ac.uk/pdbsum/2l14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l14 ProSAT]</span></td></tr>
-
{{STRUCTURE_2l14| PDB=2l14 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>
-
===Structure of CBP nuclear coactivator binding domain in complex with p53 TAD===
+
==See Also==
-
 
+
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
-
 
+
*[[P53 3D structures|P53 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20961098}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20961098 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_20961098}}
+
-
 
+
-
==About this Structure==
+
-
[[2l14]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20961098</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Dyson, H J.]]
+
[[Category: Dyson HJ]]
-
[[Category: Lee, C.]]
+
[[Category: Lee C]]
-
[[Category: Martinez-Yamout, M A.]]
+
[[Category: Martinez-Yamout MA]]
-
[[Category: Wright, P E.]]
+
[[Category: Wright PE]]

Current revision

Structure of CBP nuclear coactivator binding domain in complex with p53 TAD

PDB ID 2l14

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l14"
Personal tools