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2l3h

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(New page: '''Unreleased structure''' The entry 2l3h is ON HOLD Authors: Ramamoorthy, A., Nanga, R., Brender, J., Vivekanandan, S., Popovych, N. Description: NMR Structure in a Membrane Environme...)
Current revision (06:52, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2l3h is ON HOLD
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==NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286==
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<StructureSection load='2l3h' size='340' side='right'caption='[[2l3h]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3h OCA], [https://pdbe.org/2l3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3h RCSB], [https://www.ebi.ac.uk/pdbsum/2l3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
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Authors: Ramamoorthy, A., Nanga, R., Brender, J., Vivekanandan, S., Popovych, N.
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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Description: NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:25:18 2010''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brender J]]
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[[Category: Nanga R]]
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[[Category: Popovych N]]
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[[Category: Ramamoorthy A]]
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[[Category: Vivekanandan S]]

Current revision

NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286

PDB ID 2l3h

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