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2l3h

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{{Seed}}
 
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[[Image:2l3h.jpg|left|200px]]
 
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==NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286==
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The line below this paragraph, containing "STRUCTURE_2l3h", creates the "Structure Box" on the page.
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<StructureSection load='2l3h' size='340' side='right'caption='[[2l3h]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3h OCA], [https://pdbe.org/2l3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3h RCSB], [https://www.ebi.ac.uk/pdbsum/2l3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3h ProSAT]</span></td></tr>
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{{STRUCTURE_2l3h| PDB=2l3h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
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===NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286===
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19995078 is the PubMed ID number.
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</StructureSection>
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[[Category: Homo sapiens]]
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{{ABSTRACT_PUBMED_19995078}}
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[[Category: Large Structures]]
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[[Category: Brender J]]
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==About this Structure==
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[[Category: Nanga R]]
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2L3H is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA].
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[[Category: Popovych N]]
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[[Category: Ramamoorthy A]]
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==Reference==
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[[Category: Vivekanandan S]]
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<ref group="xtra">PMID:19995078</ref><references group="xtra"/>
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[[Category: Acid phosphatase]]
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[[Category: Brender, J.]]
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[[Category: Nanga, R.]]
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[[Category: Popovych, N.]]
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[[Category: Ramamoorthy, A.]]
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[[Category: Vivekanandan, S.]]
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[[Category: Hydrolase]]
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[[Category: Pap248-286]]
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[[Category: Sevi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:02:42 2010''
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Current revision

NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286

PDB ID 2l3h

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