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2l3h
From Proteopedia
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| - | [[Image:2l3h.png|left|200px]] | ||
| - | + | ==NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286== | |
| - | + | <StructureSection load='2l3h' size='340' side='right'caption='[[2l3h]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2l3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3h OCA], [https://pdbe.org/2l3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3h RCSB], [https://www.ebi.ac.uk/pdbsum/2l3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3h ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2l3h]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Acid phosphatase|Acid phosphatase]] | + | *[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Brender | + | [[Category: Homo sapiens]] |
| - | [[Category: Nanga | + | [[Category: Large Structures]] |
| - | [[Category: Popovych | + | [[Category: Brender J]] |
| - | [[Category: Ramamoorthy | + | [[Category: Nanga R]] |
| - | [[Category: Vivekanandan | + | [[Category: Popovych N]] |
| - | + | [[Category: Ramamoorthy A]] | |
| - | + | [[Category: Vivekanandan S]] | |
| - | + | ||
Current revision
NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286
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