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2l3j

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{{Seed}}
 
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[[Image:2l3j.jpg|left|200px]]
 
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==The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove==
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The line below this paragraph, containing "STRUCTURE_2l3j", creates the "Structure Box" on the page.
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<StructureSection load='2l3j' size='340' side='right'caption='[[2l3j]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3j OCA], [https://pdbe.org/2l3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3j RCSB], [https://www.ebi.ac.uk/pdbsum/2l3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3j ProSAT]</span></td></tr>
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{{STRUCTURE_2l3j| PDB=2l3j | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RED1_RAT RED1_RAT] Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.<ref>PMID:20501795</ref> <ref>PMID:16472753</ref> <ref>PMID:20946981</ref>
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===The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove===
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==See Also==
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*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20946981}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20946981 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20946981}}
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==About this Structure==
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2L3J is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3J OCA].
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==Reference==
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<ref group="xtra">PMID:20946981</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Allain, F H.T.]]
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[[Category: Allain FH-T]]
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[[Category: Oberstrass, F C.]]
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[[Category: Oberstrass FC]]
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[[Category: Stefl, R.]]
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[[Category: Stefl R]]
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[[Category: Dsrbm]]
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[[Category: Dsrna recognition]]
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[[Category: Editing]]
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[[Category: Hydrolase-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:03:42 2010''
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Current revision

The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove

PDB ID 2l3j

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