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2l4m

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[[Image:2l4m.png|left|200px]]
 
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==Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA==
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The line below this paragraph, containing "STRUCTURE_2l4m", creates the "Structure Box" on the page.
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<StructureSection load='2l4m' size='340' side='right'caption='[[2l4m]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4m OCA], [https://pdbe.org/2l4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4m RCSB], [https://www.ebi.ac.uk/pdbsum/2l4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4m ProSAT]</span></td></tr>
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{{STRUCTURE_2l4m| PDB=2l4m | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA===
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[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2l4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jeon, Y H.]]
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[[Category: Large Structures]]
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[[Category: Khayrutdinov, B I.]]
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[[Category: Jeon YH]]
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[[Category: Kim, K.]]
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[[Category: Khayrutdinov BI]]
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[[Category: Kim, K K.]]
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[[Category: Kim K]]
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[[Category: Kim KK]]

Current revision

Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA

PDB ID 2l4m

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